This invention relates to 6-alkynyl-pyridine of general formula (I) their use as SMAC mimetics, pharmaceutical compositions containing them, and their use as a medicaments for the treatment and/or prevention of diseases characterized by excessive or abnormal cell proliferation and associated conditions such as cancer.The groups R1 to R4 have the meanings given in the claims and in the specification.本發明係關於通式(I)之6-炔基-吡啶,其作為SMAC擬似物之用途,含其等之醫藥組合物,及其等作為治療及/或預防以細胞過度或異常增殖為特徵之疾病及相關病狀(諸如癌症)之藥劑之用途。該等基團R1至R4具有申請專利範圍及本說明書中所給定的含義。
