The present invention relates to immunogens directed against lung cancer associated proliferative peptides and growth factors and its uses thereof in conjunction with chemotherapeutics in the early and advanced treatment of various malignant diseases, especially including lung cancers, both small cell lung carcinomas (SCLC), non-small cell lung (NSCLC) cancers and neuroendocrine-type cancers.本發明是關於針對肺癌相關的增殖肽和生長因子的免疫原,以及其與化學療法用於各種惡性疾病的早期和晚期治療的用途,特別是包括肺癌,小細胞肺癌(SCLC)及非小細胞肺癌(NSCLC)兩者,以及神經內分泌型癌症。