COTE DES COMBES, SYLVAIN,FROISSANT, JACQUES,GIBERT, JEAN-FRANÇOIS,MARGUET, FRANK,PACAUD, CHRISTOPHE,PUECH, FREDERIC,RAVET, ANTOINE
申请号：
PE0022572012
公开号：
PE02592013A1
申请日:
2011.06.01
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Refers to compounds of 3,4 - 5-methyl-4-oxo-1,4-dihydropyrrolo [1,2-a] pyrazine - (1H) - 2.8 dicarboxamida of formula (i) where R2 is alkyl, cycloalkyl (C1 - C10) (C3 - C10), Alquiltio (C1 - C6) alkyl (C1 - C10), fluoroalquilo (C1 - C10) among others X6 is h, F, CL, alkyl, cycloalkyl (C1 - C6) (C3 - C7), among others and R7 S phenyl or naphthyl optionally replaced with X7, where X7 is Halogen, Hydroxy alkyl (C1 - C6)Cycloalkyl (C3 - C7), among others. Preferred compounds are: N2 - Tert Butyl - 4 - phenyl - 3.4 - 5-methyl-4-oxo-1,4-dihydropyrrolo [1,2-a] pyrazine - (1H) - 2.8 dicarboxamida N2 - Tert Butyl - Cycle - propyl - 6 - 7 - [3 - (trifluoromethyl) phenyl] - 3.4 - 5-methyl-4-oxo-1,4-dihydropyrrolo [1,2-a] pyrazine - 2.8 (1H) - dicarboxamida 7 - (4-butoxyphenyl) - N2 - tert - butyl - 4 - Cycle - propyl - 3.4 - pirazin 5-methyl-4-oxo-1,4-dihydropyrrolo [1,2-a] To - 2.8 (1H) - dicarboxamida among others.It also relates to a preparation method and a Pharmaceutical composition. These compounds are inhibitors of the Enzyme casein kinase 1 (ck1epsilon Epsilon Delta) and casein kinase 1 (ck1delta) being useful in the treatment of Sleep Disorders, sclerosis, Encephalitis, myelitisSE REFIERE A COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRROLO[1,2-a]PIRAZINA-2,8(1H)-DICARBOXAMIDA DE FORMULA (I) DONDE R2 ES ALQUILO(C1-C10), CICLOALQUILO(C3-C10), ALQUILTIO(C1-C6)-ALQUILO(C1-C10), FLUOROALQUILO(C1-C10), ENTRE OTROS X6 ES H, F, Cl, ALQUILO(C1-C6), CICLOALQUILO(C3-C7), ENTRE OTROS R7 ES FENILO O NAFTILO OPCIONALMENTE SUSTITUIDO CON X7, EN DONDE X7 ES HALOGENO, HIDROXI, ALQUILO(C1-C6), CICLOALQUILO(C3-C7), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N2-TERC-BUTIL-7-FENIL-3,4-DIHIDROPIRROLO[1,2-a]PIRAZINA-2,8(1H)-DICARBOXAMIDA N2-TERC-BUTIL-6-CICLO-PROPIL-7-[3-(TRIFLUOROMETIL)FENIL]-3,4-DIHIDROPIRROLO[1,2-a]PIRAZINA-2,8(1H)-DICARBOXAMIDA 7-(4-BUTOXIFENIL)-N2-TERC-BUTIL-6-CICLO-PROPIL-3,4-DIHIDROPIRROLO[1,2-a]PIRAZINA-2,8(1H)-DICARBOXAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO
