A biopsy instrument (1) comprising a base member (10) which extends from a proximal end (10a) to a distal end (10b) along a central geometrical axis (A), wherein at least a distal end portion (10b') of the base member (10) is shaped as an elongated hollow tube (10), the distal end (10b) being intended to be at least partly inserted into a tissue (50) from which a biopsy is to be obtained, wherein the hollow tube (10) is provided with a distally facing circular cutting edge (11) defining a mouth (10c) of the distal end (10b) of the hollow tube (10), wherein the hollow tube (10) has, at a distal portion (10b') of the hollow tube (10), a hollow elongated tubular sample acquiring portion (10b') having a smooth interior surface (12). The disclosure also relates to a kit of parts and a method of acquiring a biopsy.
