Mutant low-density lipoprotein receptor related protein with increased binding to Alzheimer amyloid-beta peptide

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专利权人:

ZZ Alztech L.L.C.

发明人:

Zlokovic, Berislav,Srivastana, Alaka,Deane, Rashid

申请号：

AU2010307332

公开号：

AU2010307332A1

申请日:

2010.10.18

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

A mutant low-density lipoprotein receptor related protein-1 binds to Alzheimer amyloid-beta (Aβ) peptide with greater affinity compared to its wild- type homolog. This binding may be used to detect Aβ or to separate Aβ from the rest of a subject's body. In Alzheimer disease, it may be used to provide diagnostic results by detecting Aβ, treatment by removing Aβ, or both.

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