The present invention provides a medical diagnostic device with an automatic moving mechanism. The device comprises an input interface for receiving instructions from an operator or from a remote device. A motion controller is coupled to the input interface for controlling movements of the diagnostic device based on the instructions received through the input interface. A moving assembly is coupled to the motion controller for moving the diagnostic device under control of the motion controller. In an embodiment, a method of guiding a portable imaging system through various locations in a hospital is disclosed. Also the invention discloses a self-guided portable imaging system.