#$%^&*AU2015213378B220171207.pdf#####ABSTRACT A handheld device for extraction of tissue samples is disclosed, comprising a needle arrangement and control arrangement, said needle arrangement comprising a cutting needle and a sample extraction needle, said needle arrangement having a first end, for inserting into tissue, said cutting needle comprising a cutting edge for cutting said tissue sample from said tissue, said sample extraction needle comprising a side opening for receiving said tissue, said control arrangement comprising a vacuum chamber in fluid communication with said sample extraction needle, the vacuum chamber comprising a first member and a second member, said first and second members being adapted to move relative to each other, wherein said first member is mechanically connected to said cutting needle, and wherein said handheld device is configured so that -a movement between said first member and said second member to increase the volume of said vacuum chamber and thereby reduce the pressure in said sample extraction needle induces -a movement between said cutting needle and said sample extraction needle to expose said side opening of said sample extraction needle.