LLC;CALICO LIFE SCIENCES;ABBVIE, INC.;CALICO LIFE SCIENCES, LLC
发明人:
DART, MICHAEL J.,CHUNG, SEUNGWON,HUTCHINS, CHARLES W.,TONG, YUNSONG,ZHANG, QINWEI I.,SHI, LEI,SWEIS, RAMZI FARAH,XU, XIANGDONG,BLACK, LAWRENCE A.,FROST, JENNIFER M.,PLIUSHCHEV, MARINA,SIDRAUSKI, CARME
申请号：
ARP170101184
公开号：
AR108395A1
申请日:
2017.05.05
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
1. This document provides useful compounds, compositions, and methods for the regulation of integrated stress response (ISR) and the treatment of related diseases, disorders, and conditions. 1. Claim 1: a formula compound (1),or one of its pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers, wherein: D is a monocyclic bridge cycloalkyl, monocyclic bridge or cubanyl heterocycle, wherein each monocyclic bridge cycloalkyl, monocyclic bridge or cubanyl heterocycle is optionally substituted with 1-4 RX； L¹ is C₁₋₆ alkylene,C₁₋₆ alkenylene or 2-7 membered heteroalkylene, wherein each C₁₋₆ alkylene,C₁₋₆ alkenylene or 2-7 membered heteroalkylene is optionally substituted with 1-5 RX； R¹ and R² are each, independently, hydrogen, C₁₋₆ alkyl,C₁₋₆ alkoxy-C₁₋₆ alkyl,hydroxy-C₁₋₆ alkyl or silyloxy-C₁₋₆ alkyl；Q is C (o) or s (o) 83222；A and W are independent phenyl or isomers, each of which can be replaced by 1-5 ry, and each Rx is selected from c83321316a and c8326a separately；hydroxy-C₁₋₆ alkyl,halo-C₁₋₆ alkyl,amino C₁₋₆ alkyl,cyano-C₁₋₆ alkyl,oxo, halo, cyano, -ORA, -NRBRC, -NRBC (O) RD, -C (O) NRBRC, -C (O) RD, -C (O) OH, -C (O) ORD, -SRE, -S (O) RD and -S (O) ₂RD； each RY is independently selected from the group consisting of hydrogen, C₁₋₆ alkenyl,hydroxy-C₁₋₆ alkyl,C₁₋₆ hydroxy-alkenyl,halo-C₁₋₆ alkyl,C₁₋₆ haloalkoxy,amino C₁₋₆ alkyl,C₁₋₆-alkyl amido,cyano-C₁₋₆ alkyl,C₁₋₆ silyloxy-alkoxy,Cxil hydroxyl-alkoxy,oxo, halo, cyano, -ORA, -NRBRC, -NRBC (O) RD, -C (O) NRBRC, -C (O) RD, -C (O) OH, -C (O) ORD, -S ( RF) ₘ,-S (O) RD, -S (O) ₂RD, S (O) NRBRC, -NRBS (O) ₂RD, -OS (O) RD, -OS (O) ₂RD, G¹ or C₁₋₆-G¹ alkylene；or 2 RY groups in adjacent atoms, together with the atoms to which they are attached, form a 3-7 membered fused cycloalkyl ring, a 3-7 membered fused heterocyclyl ring or a fused 5-6 membered heteroaryl ring, each one optionally substituted with 1-5 RX； each G¹ is, independently, 3-7 membered cycloalkyl, 4-7 membered heterocyclyl, 5-6 membe
