Andrea Nelson,Quin-Zene Chen,Harsh Mehta,Yu-Hsing Tu
申请号:
US14863784
公开号:
US09408823B2
申请日:
2015.09.24
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A 12-hour anti-tussive modified release solid tablet or capsule is described which comprises a benzonatate adsorbate in a matrix with a sufficient amount of one or more pharmaceutically acceptable modified release pH-independent, substances to provide a 12-hour modified release profile to the benzonatate, wherein there is substantially no benzonatate release from the tablet or capsule in the buccal cavity and no more than about 25% release of the benzonatate within 1 hour as determined in an in vitro dissolution assay.