Andrea Nelson,Quin-Zene Chen,Harsh Mehta,Yu-Hsing Tu
申请号：
US15075697
公开号：
US09867797B2
申请日:
2016.03.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A 12-hour anti-tussive modified release solid tablet or capsule is described which comprises a benzonatate adsorbate in a matrix with a sufficient amount of one or more pharmaceutically acceptable modified release pH-independent, substances to provide a 12-hour modified release profile to the benzonatate, wherein there is substantially no benzonatate release from the tablet or capsule in the buccal cavity and no more than about 25% release of the benzonatate within 1 hour as determined in an in vitro dissolution assay.
