A thermo-reversible thermoplastic pharmaceutical composition, comprising abotulinum toxin and a biocompatiblepoloxamer which provides thermoreversibility to the composition andadditionally stabilizes the botulinum toxin, is described.The pharmaceutical composition can be administered to a patient as a liquid,and gels after administration into a sustained releasedrug delivery system from which the biologically active botulinum toxin isreleased over a multi-day period thereby localizing thedrug as a depot and controlling release to enhance the therapeutic effect perdose.
