CRAIG M CREWS,ANDREW P CREW,HANQING DONG,JING WANG,YIMIN QIAN,KAM SIU,JIN MEIZHONG
申请号：
IN201747047380
公开号：
IN201747047380A
申请日:
2017.12.30
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The description relates to imide based compounds including bifunctional. compounds comprising the same which find utility as modulators of targeted ubiquitination especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular the description provides compounds which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.
