作為血液學毒性生物標記之GDF-15

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专利权人:

Novartis AG

发明人:

GUERREIRO, Nelson,MEILLE, Christophe,WUERTHNER, Jens

申请号：

HK18108032

公开号：

HK1249583A1

申请日:

2018.06.22

申请国别(地区):

HK

年份:

2018

代理人:

摘要：

The present disclosure relates to use of GDF-15 as a safety biomarker for determining a toxicological effect of a Mdm2 inhibitor； an ex vivo method for determining a toxicological effect of a Mdm2 inhibitor in a subject, in particular for determining a likelihood of developing thrombocytopenia in a subject in response to administration of a dose of a Mdm2 inhibitor； methods of using a Mdm2 inhibitor in the treatment of cancer in a subject； a kit for use in predicting the likelihood that a patient having cancer will develop thrombocytopenia in response to a treatment with a dose of a Mdm2 inhibitor； a kit for use in treating a patient having cancer and related disclosure embodiments.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/