ABBOTT LABORATORIES;ABBVIE INC.;ABBOTT GMBH & CO. KG
发明人:
申请号：
IL20888410
公开号：
IL208884A
申请日:
2010.10.21
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application arc useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid ² and advanced glycation-end-products.
