Enrico L. DiGiammarino;Gerard B. Fox;John E. Harlan;Zhen Wu;Volker Nimmrich;Feng Luo;Ralf Loebbert;Reinhold Mueller;Ulrich Ebert;Jijie Gu;Chung-Ming Hsieh;Martin Schmidt
发明人:
Jijie Gu,Chung-Ming Hsieh,Zhen Wu,Enrico L. DiGiammarino,Feng Luo,Gerard B. Fox,John E. Harlan,Martin Schmidt,Ralf Loebbert,Reinhold Mueller,Ulrich Ebert,Volker Nimmrich
申请号：
US12437715
公开号：
US08323651B2
申请日:
2009.05.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid β and advanced glycation-end-products.
