The present invention discloses a method for freeze-drying drug liposomes powder assisted by a variable-frequency altemating-current electric field, which comprises the following steps: (1) preparing a drug-liposome suspension sample； (2) dehydrating the sample under a 1-10 kHz, 3-10 kV high-voltage alternating current； (3) freezing and drying the sample treated in step (2) at -20 °C to -40 °C, under a 10-25 kHz, 0.2-1 kV high-voltage alternating current, until completion of the freezing process； and (4) heating and drying the sample in a vacuum until completion of sublimation and desorption, and obtaining the drug liposomes freeze-dried powder. The present invention not only greatly shortens a freezing and drying time, but also controls a size of nuclei and ice crystals, further ensuring a quality of the freeze-dried powder.
