Brian H. White,Benoît Moreau,Mark T. Bilodeau,Sudhakar Kadiyala
申请号：
US16301144
公开号：
US20200009262A1
申请日:
2017.05.12
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Targeted constructs and pharmaceutical formulations thereof, comprising at least one conjugate of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety via an optional internal linker moiety have been designed which can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the targeted constructs and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.
