Kaiyong Tang,Junfang Pan,Qin Zhu,Tong Fang,Chengcheng Niu,Wanhai Li,Wei Lv,Chen Qing,Guorong Fan
申请号：
US14389468
公开号：
US20150057305A1
申请日:
2013.03.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed in the present invention is a pharmaceutical composition, comprising a weight ratio of 1:120 to 1:1000 of camptothecin compound of formula I and β-cyclodextrin or derivatives thereof, and an acidic buffer to adjust the pH=3.5-6.0. The composition can be used to treat solid tumours, such as melanoma, pancreatic cancer, hepatoma etc. The pharmaceutical composition of the present invention is miscible with a water-miscible co-solvent system in any proportion, and can be used as an intravenous infusion solvent, and has no obvious hemolysis or vascular stimulation the pharmaceutical composition has a better tumour inhibiting rate than solubilisation of surfactants.
