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METHOD FOR ENHANCING IMMUNE RESPONSES IN MAMMALS
专利权人:
发明人:
申请号:
EP06825089.3
公开号:
EP1940463B1
申请日:
2006.09.22
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention provides a method for enhancing an immune response in a mammal to facilitate the elimination of a chronic pathology. The method involves the removal of immune system inhibitors such as soluble TNF receptor from the circulation of the mammal, thus, enabling a more vigorous immune response to the pathogenic agent. The removal of immune system inhibitors is accomplished by contacting biological fluids of a mammal with one or more binding partner(s) such as TNFalpha muteins capable of binding to and, thus, depleting the targeted immune system inhibitor(s) from the biological fluids. Particularly useful in the invention is an absorbent matrix composed of an inert, biocompatible substrate joined covalently to a binding partner, such as a TNFalpha mutein, capable of specifically binding to a targeted immune system inhibitor such as soluble TNF receptor.
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