BIAN Khajan (US),БИАН Хайан (US),ShEVAL'E Kristen M. (US),ШЕВАЛЬЕ Кристен М. (US),KONNOLLI Piter Dzh. (US),КОННОЛЛИ Питер Дж. (US),FLORES Kristofer M. (US),ФЛОРЕС Кристофер М. (US),LIN' Shu-chehn' (US,BIAN KHAJAN,БИАН Хайан,SHEVALE KRISTEN M.,ШЕВАЛЬЕ Кристен М.,KONNOLLI PITER DZH.,КОННОЛЛИ Питер Дж.,FLORES KRISTOFER M.,ФЛОРЕС Кристофер М.,LIN SHU-CHEHN,ЛИНЬ Шу-чэнь,LJU LI,ЛЮ Ли,MEJBUS DZHON,МЕЙБУС
申请号：
RU2011147206/04
公开号：
RU0002569298C2
申请日:
2010.04.22
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to formula (I) compounds, where Y and Z are independently selected from group a) or b) in such a way that one of Y or Z is selected from group a) and the other is selected from group b)； group a) represents i) substituted C6-10aryl； ii) C3-8cycloalkyl, optionally substituted with one or two substituents, representing fluorine； iii) trifluoromethyl； or iv) heteroaryl, selected from the group, consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, pyrimidinyl, isoxazolyl, benzothienyl, thieno[3,2-b]thiophen-2-yl, pyrazolyl, triazolyl and [1,2,3]thiadiazolyl； where C6-10aryl is substituted, and heteroaryl is optionally substituted with one substituent, selected from the group, consisting of fluorine, chlorine, bromine, C1-4alkyl, C1-4alkoxy and C1-4alkylcarbonylamino； group b) represents i)C6-10aryl； ii) heteroaryl, selected from the group, consisting of thiazolyl, pyridinyl, indolyl, indazolyl, benzoxazolyl, benzothiazolyl, benzofuranyl, benzothienyl, 1H-pyrrolo[3,2-b]pyridin-5-yl, 1H-thieno[2,3-c]pyrazol-5-yl, 1H-pyrrolo[2,3-b]pyridine-5-yl, 1H-pyrazolo[3,4-b]pyridine-5-yl, furo[2,3-b]pyridine-2yl, furanyl, [1,2,3]triazolyl, thienyl, oxazolyl, [1,3,4]oxadiazol-2-yl, pyrrolyl, pyrazolyl and benzimidazolyl； iii) 2,3-dihydro-1H-indolyl； vi) 1-(2,4-dichlorophenyl)-4,5,6,7-tetrahydro-1H-indazol-3-yl； or ix) diphenyl-1H-pyrazol-3-yl； in which each phenyl is optionally substituted with one or two substituents, representing chlorine, and in which said pyrazolyl is optionally substituted with one substituent, representing methyl, where C6-10aryl, 2,3-dihydro-1H-indolyl and heteroaryl from group b) are optionally independently substituted with one or two substituents, selected from the group, consisting of bromine, chlorine, fluorine, iodine, C1-4alkyl, C1-4alkoxy and trifluoromethyl； and where C6-10aryl and heteroaryl are substituted with one additional substituent, selected from the group, consisting of i)
