The invention provides a multi-sensory stimulation system with simultaneous acousto-optic vibration, which comprises at least an integrated vibrator. Via the electrical connection of a sound module, a first signal is transmitted to the somatosensory vibrator, so that the frequency and amplitude of the sound waves generate sound and vibration to stimulate hearing and proprioception. The control element receives the second signal of the sound module, and then transmits the control signal to a light-emitting element electrically connected to control the color and flicker of the light. In the present invention, at least one optical fiber member is connected to the light emitting end of the light emitting element, and the light is transmitted to the user's eyes through the at least one optical fiber member to stimulate vision. At the same time, the user can operate the optical fiber with his hand to stimulate the tactile sensation on the body surface.本發明提供一種聲光震動同步之多感官刺激系統,其係包含至少一體感震動器。經由一聲音模組的電性連接,傳送第一訊號至該體感震動器,使其聲波的頻率與振幅產生聲音及震動,以刺激聽覺與本體感覺。該控制元件接收該聲音模組之第二訊號,再傳送控制訊號至電性連接之一發光元件,控制其光線的顏色與閃爍。本發明更以至少一光纖件連接該發光元件之出光端,,將該光線經由該至少一光纖件傳送至使用者眼中,以刺激視覺。同時,使用者可用手操作光纖,以刺激體表觸覺。