PROBLEM TO BE SOLVED: To provide methods for treating or preventing progression of oxidative retinal diseases.SOLUTION: A method of the invention comprises administering an effective amount of a polyunsaturated substance to a patient in need of treatment of wet or dry age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, cataract or Stargardt disease, where the polyunsaturated substance is chemically modified such that one or more bonds are stabilized against oxidation, and the polyunsaturated substance or polyunsaturated metabolite thereof comprising one or more stabilized bonds is incorporated into the patient's body after the administration. In some embodiments, the polyunsaturated substance is preferably a fatty acid, fatty acid mimetic or fatty acid prodrug.SELECTED DRAWING: Figure 1A【課題】酸化的網膜疾患の進行を治療または予防する方法の提供。【解決手段】有効量の多価不飽和物質を、治療を必要とするウェット型またはドライ型の加齢性黄斑変性症、網膜色素変性症、糖尿病性網膜症、白内障、またはＳｔａｒｇａｒｄｔ病の患者に投与することを含み、ここで、多価不飽和物質は、１つ以上の結合が酸化に対して安定化されるように化学的に修飾されており；前記１つ以上の安定化された結合を含む多価不飽和物質またはその多価不飽和代謝物が、投与後に患者の体内に取り込まれるものとする、方法。前記多価不飽和物質が脂肪酸、脂肪酸模倣物、又は脂肪酸プロドラックであることが好ましい、方法。【選択図】図１Ａ
