FRED HUTCHINSON CANCER RESEARCH CENTER;UNIVERSITY OF UTAH RESEARCH FOUNDATION
发明人:
Stephen J TAPSCOTT,Jennifer L WHIDDON,Peter G HENDRICKSON,Edward J GROW,Bradley R CAIRNS
申请号：
US16342856
公开号：
US20200087629A1
申请日:
2017.10.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
It was found that DUXC family proteins were efficient activators of EGA and that DUXC proteins could be used in methods in the reprogramming of cells to a totipotent state and to increase the efficiency of somatic cell nuclear transfer (SCNT). Accordingly, aspects of the disclosure relate to a method for reprogramming a cell into a totipotent state, the method comprising expressing a DUXC family protein in the cell. Further aspects of the disclosure relate to a method for making a host cell nuclear transfer (SCNT) embryo comprising expressing a DUXC protein in a somatic cell and transferring the nucleus of the somatic cell to an enucleated oocyte, thereby making a SCNT embryo.
