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OGRANICZONY ŁAŃCUCH CIĘŻKI IMMONOGLOBULINY POCHODZĄCEJ OD MYSZY
专利权人:
Inc.;Regeneron Pharmaceuticals
发明人:
MACDONALD LYNN,MCWHIRTER JOHN,GURER CAGAN,MEAGHER KAROLINA A.,MURPHY ANDREW J.
申请号:
PL12783456
公开号:
PL2627773T3
申请日:
2012.10.17
申请国别(地区):
PL
年份:
2017
代理人:
摘要:
Mice having a restricted immunoglobulin heavy chain locus are provided, wherein the locus is characterized by a single polymorphic human V H gene segment, a plurality of human D H gene segments and a plurality of J H gene segments. Methods for making antibody sequences that bind an antigen ( e.g ., a viral antigen) are provided, comprising immunizing a mouse with an antigen of interest, wherein the mouse comprises a single human V H gene segment, a plurality of human D H gene segments and a plurality of J H gene segments, at the endogenous immunoglobulin heavy chain locus.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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