In an embodiment, the tissue layer opening method and the method of moving molecules into the tissue include the following: treating the surface of the tissue with a plasma and supplying a carrier comprising one or more molecules to the surface of the tissue Discloses a method of applying treatment. [Selection] Figure 3実施例では、組織層の開孔方法と分子を組織内に移動する方法は以下の、プラズマを前記組織の前記表面に処置し、及び、一又は複数の分子を含むキャリアを前記組織の前記表面に塗布処置される方法が開示されている。【選択図】図3