Dino Di Carlo,Westbrook Weaver,Donald Griffin,Jaekyung Koh
申请号：
US16071252
公开号：
US20200305773A1
申请日:
2017.01.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A biocompatible analyte sensing material for intradermal or subcutaneous application includes a collection of microgel particles having one or more network crosslinker components and an endogenous or exogenous annealing agent that links the microgel particles together in situ to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. A plurality of analyte-specific fluorophores are conjugated to the microgel particles, wherein the analyte-specific fluorophores, in the presence of the analyte and subject to excitation radiation, emit fluorescent light. The analyte sensing material may, in some embodiments, be applied to an excision made in the skin or injected into the skin of a subject.
