Antisense compounds, compositions and methods are provided for modulating theexpression of superoxide dismutase 1, soluble. The compositions compriseantisense compounds, particularly antisense oligonucleotides, targeted tonucleic acids encoding superoxide dismutase 1, soluble. Methods of using thesecompounds for modulation of superoxyde dismutase 1, soluble expression and fortreatment of diseases associated with expression of superoxide dismutase 1,soluble are provided.