Various crystal forms of antihexachlorobenzene compounds (1ar, 5S, 8s, 9s, 1R, 22ar) - 5-terc-util-n - [(1R, 2R) - 2 - (difluoromethane) - 1 - [(1-methylcyclopropanol) aminomethanol] - 1 - [(1-methylcyclopropyl) aminomethanol] - 9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a, 3,4,5,9,10,18,22,21,21Solid state properties of hydrogen tetroxide-8h-7, 10-methanecyclopropane [18.19] [1.10, 3.6] dioxin [11.12-b] quinoxalina-8-carboxamida (compound I): a manufacturing process and a method using crystal form are also provided.Se prepararon formas cristalinas del compuesto anti-HCV (1aR,5S,8S,9S,10R,22aR)-5-terc-butil-N-[(1R,2R)-2-(difluorometil)-1-{[(1-metilciclopropil)sulfonil]carbamoil}ciclopropil]-9-etil-18,18-difluoro-14-metoxi-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahidro-8H-7,10-metanociclopropa[18,19][1,10,3,6]dioxadiazaciclononadecino[11,12-b]quinoxalina-8-carboxamida (Compuesto I) y se caracterizaron en estado sólido:También se proporcionan procesos de fabricación y métodos para usar las formas cristalinas.
