EVA DR. BECKER,RENE MARIA - DR. MARTIN,MICHAEL DR. HAHN,JOHANNES PROF. DR. STASCH,MARTINA PETER - DR. DELBECK,HANNA DR. TINEL,FRANK DR. WUNDER,JOACHIM PROF. DR. MITTENDORF,ILDIKO DR. TEREBESI,MARKUS D
申请号：
ARP130102566
公开号：
AR091838A1
申请日:
2013.07.18
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
1. This specification refers to 5-aminohydrogen-2-carboxylic acid, its preparation procedure, its use in the treatment and / or prevention of diseases, and its drug used in the development of treatment and / or prevention of diseases, Especially for the treatment and / or prevention of cardiovascular and pulmonary diseases. Claim 1: it consists of formula (1) where R1 represents hydrogen or fluorine； L1 represents ethane-1, 2-dioxygen or 1, 4-phenyl； a represents a formula group (2),(3) Or (4),a. * denotes the binding point of each molecule with other molecules； L2 denotes c832131 alkane； L3 denotes a binding, - or -；-CH₂-,-CH₂-CH₂- o -CH = CH-；R2 means lease c83217c83318324,which can be substituted up to six times with fluorine, or means C₃₋₆ cycloalkyl,a. Fluorine, difluoromethane, trifluoromethane, and other selected parts of the tar series may be unisexual or soluble in the same or different ways；O refers to heterosexuals consisting of four to six members, one to two of whom are the same or different heterosexuals selected from the N series (r830808)；O, S and S (O) ₂ in which R⁴ represents C₁₋₄ alkyl or C₁₋₄ alkylcarbonyl or in the case where N (R⁴) represents an annular nitrogen atom by means of which the mentioned heterocyclyl is linked to the adjacent phenyl group, is not present, or means a 5-membered heteroaryl containing one, two or three same or different annular heteroatoms selected from the N, O and S series and may optionally be fused to a phenyl ring, the heteroaryl ring may be and the phenyl ring optionally condensed, respectively, be mono or disubstituted, in the same or different manner with a moiety selected from the fluorine, chlorine, cyano series,difluorometilo, trifluorometilo, alquilo C₁₋₄,Difluoromethy, trifluorometoxi and alcoxi c83332216c83318324；o means chlorine； and R³A, R³B, R³C and R³D independently mean hydrogen or a substituent selected from the series fluorine, chlorine, bromine, cyano, C alquilo alkyl,2. Difluoromethane, trifluorom
