The present disclosure relates to evidenced-based neuro-cognitive testing methodologies and systems. The present disclosure provides for a protocol and testing service. The protocol and testing service provides empirical data support for the interventions of the treating physician or clinician. The evidenced-based neuro-cognitive testing methodology and system disclosed comprises a protocol for the use of a triggering questionnaire. Further, the evidenced-based neuro-cognitive testing methodology and system provides normed screenings to guide and support the interventions provided by the treating physicians or clinicians. The protocol provides for intervention support, interpretations, and empirical data that enhance best practices.