It describes the ingredients and methods for the treatment of depression, using compounds including type I formula of phenylpropylamine compounds and derivatives, which, contrary to the 5-HT1A receptor, have a selective affinity for antagonism and activity, as well as 5-HT inhibitory absorption activity. In addition, the composition and method of using the composition containing the second formula compound to treat depression are also described. They are also described as depression used to treat or reduce at least one symptom in the human body, consisting of a compound of formula (I) or formula (II),Or pharmaceutically acceptable salts, hydrates, or solutionsSe describe composiciones y metodos para el tratamiento de la depresion, utilizando composiciones que comprenden compuestos de fenoxipropilamina de formula I y derivados que tienen afinidad selectiva para y actividad antagonista, en contra del receptor 5-HT1A, asi como la actividad inhibitoria de la recaptacion de 5-HT. Adicionalmente, se describe, las composiciones y metodos para tratar la depresion utilizando composiciones que comprenden un compuesto de la formula II. Tambien son descritos, metodos para el tratamiento o disminucion de a lo menos un sintoma de la depresion en un sujeto humano, con una composicion que comprende un compuesto de la formula (I) o formula (II), o una sal farmaceuticamente aceptable, hidrato, o solvato de la misma
