Describes compositions and Methods for the treatment of depression, using compositions comprising compounds of formula I and fenoxipropilamina derivatives having Affinity for and Selective antagonist activity, against the 5-ht2a receptor, as well as the Inhibitory activity of L A reuptake of 5-ht.Additionally, it describes compositions and Methods for treating Depression using compositions comprising a compound of formula II.Also described are methods for the Treatment or a decrease of at least one symptom of depression in a Human subject with a composition comprising a compound of formula (i) or formula (ii), or a pharmaceutically acceptable Salt, hydrate or solvate thereofSe describe composiciones y metodos para el tratamiento de la depresion, utilizando composiciones que comprenden compuestos de fenoxipropilamina de formula I y derivados que tienen afinidad selectiva para y actividad antagonista, en contra del receptor 5-HT1A, asi como la actividad inhibitoria de la recaptacion de 5-HT. Adicionalmente, se describe, las composiciones y metodos para tratar la depresion utilizando composiciones que comprenden un compuesto de la formula II. Tambien son descritos, metodos para el tratamiento o disminucion de a lo menos un sintoma de la depresion en un sujeto humano, con una composicion que comprende un compuesto de la formula (I) o formula (II), o una sal farmaceuticamente aceptable, hidrato, o solvato de la misma
