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Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
专利权人:
Eli Lilly and Company
发明人:
Krasutsky, Alexei Pavlovych,York, Jeremy Schulenburg,Wallace, Owen Brendan,Xu, Yanping,Allen, John Gordon
申请号:
AU2007244960
公开号:
AU2007244960B2
申请日:
2007.04.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention discloses novel compounds of Formula I: ( I ) possessing11β -HSD type 1 antagonist activity, as well as methods for preparing suchcompounds. In another embodiment, the invention discloses pharmaceuticalcompositions comprising compounds of Formula I, as well as methods of using thecompounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension,hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditionsassociated with 11 β -HSD type 1 activity.
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