A wheelchair control system and a control method using the same is provided. Firstly, providing a wheelchair which has a back provided with a first sensor and at least one second sensor arranged above the first sensor. The first sensor and the second sensor are electrically connected with a control device. A sitter sits in the wheelchair to trigger the first sensor and the second sensor, whereby the control device controls the wheelchair to operate. When the first sensor and the second sensor are triggered or non-triggered, the control device controls the wheelchair to stop or operate. The present invention controls the wheelchair to operate by changing the posture of the sitter, improves the conventional wheelchair to move by another person, and provides an automatic wheelchair for a sitter with upper limbs that inconveniently move. The sitter only moves his back to control the wheelchair to operate.