A reactive antibacterial compound and a preparation method thereof are provided herein. The reactive antibacterial compound is represented by the general formula (I) or (II):wherein R1 represents OCN-L-NHCOOR′；, OCN-L-NHCONHR′；, OCN-L-NHCOSR′；, OCN-L-COOR′；, or OCN-L-COONHR′；. G1 represents OCN-M-NHCOOG′；, OCN-M-NHCONHG′；, OCN-M-NHCOSG′；, OCN-M-COOG′；, or OCN-M-COONHG′；. L, M, R′； and G′； independently for each occurrence represent divalent alkyl and cycloalkyl having from 1 to 18 carbon atoms, optionally substituted by up to 18 heteroatoms. R4 and G4 independently for each occurrence represent a divalent alkyl and cycloalkyl having from 1 to 18 carbon atoms, optionally substituted by at most 18 heteroatoms. G2 and G3 independently for each occurrence represent —；H, —；F, —；Cl, —；Br, —；I, —；OCH3, —；OCH2CH3, —；OPr, —；CN, —；SCN, —；NO, —；NO2, a monovalent unsubstituted or substituted alkyl, cycloalkyl, or aryl having from 1 to 7 carbon atoms. Z and X independently for each occurrence represent —；COO, —；SO3, or —；OPO2OR5. R5 represents a monovalent unsubstituted or substituted alkyl, cycloalkyl, or aryl having from 1 to 6 carbon atoms.
