FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III
发明人:
PEVARELLO, PAOLO,GARCIA COLLAZO, ANA MARÍA,GARCIA GARCIA, ANA BELÉN
申请号：
ES08806437
公开号：
ES2548768T3
申请日:
2008.09.29
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I, ** Formula ** in which: B represents -S-； Z represents a direct link, -O-, -S-, - (CH2) nN (Ra10) - or - (CH2) n-NH-CO- in which, in each case, the first script is linked to 5, 5-cycle required； n represents, on each occasion when used herein, 0, 1 or 2； M represents a direct bond or C1-3 alkylene； R1 represents -CO2H or an amide thereof, C1-6 alkyl (optionally substituted with one or more substituents selected from A1), C3-6 cycloalkyl, heterocycloalkyl (the last two groups being optionally substituted with one or more substituents selected from B1 and B2, respectively), aryl or heteroaryl (the last two groups being optionally substituted with one or more substituents selected from B3 and B4, respectively)； X represents a direct bond, -O-, - (CH2) mN (Rd) -, - (CH2) m-NH-SO2-, - (CH2) m-NH-CO-, - (CH2) m-CO- N (Rd) - or C1-3 alkylene in which, in each case, the first indent is attached to the required 5,5-bicycle； m represents, on each occasion when used herein, 0, 1 or 2； R2 represents halo, C1-6 alkyl (optionally substituted with one or more substituents selected from A3), C3-6 cycloalkyl, heterocycloalkyl (optionally substituted with one or more substituents selected from B6), aryl or heteroaryl (the last two groups being optionally substituted with one or more substituents selected between B7 and B8, respectively)； but in which: (i) when X represents a direct bond, then R2 does not represent halo； A1 and A3 independently represent halo, -ORe, -C (O) 2Re, -N (Re) -C (O) -Re or phenyl (optionally substituted with one or more substituents -ORe)； B1, B2, B3, B4, B6, B7 and B8 independently represent halo, -ORe, -C (O) 2Re, -C (O) Re, -CN, -S (O) 2Re, - SO2N (Re) 2 , -N (Re) 2 and / or C1-3 alkyl optionally substituted with one or more substituents selected from halo, -ORe and -C (O) 2Re； or, B1, B2 and B6 can represent alternatively and independently>； = O； R3 represents hydrogen, C1-2 alkyl or fluorine； Ra, Rd and Re independently repres
