Claim 1: wherein is a compound of formula (1): where X is n or CR1 and CR2 or； n； Z is o, s or NH； r1 is H, or C1 - 6 alkyl alkyl； R2 is H, or C1 - 6 - 8； R3 is alkyl alquenilo C1, C2 C3 - 8 8, cycloalkyl, aryl or heteroaryl,(a) where the alkyl C1 or C2 - 8 - 8 alquenilo is optionally substituted with one or more substituents selected from the group consisting of halogen, Nitro, cyano, ora, - ra, - C (o) C (o) - ora, OC (OR) - ra, - nrbrc, NRBC (o) - NHC (or RA) nhrb, - C (o) nrbrc nhso2ra, -, and - so2nrbnrc； and (b) cycloalkyl C3 8, aryl,Heteroaryl and are optionally substituted with one or more substituents selected from the group consisting of alkyl - 6 haloalquilo C1, C1 - C2 - alquenilo 6, 6, heterocicloalquilo, aryl, heteroaryl, halogen, Nitro, cyano -, Oxo, Ord, RD, - C (o) - C (o) - ORD oC (SRD) Rd, - S, - (OR) - so2rd Rd,, - n RERF, NHC (re -) - NHC (OR) nhre - NHC (or ore, nhso2rd) -, - C (o) - nhre, and so2nhnre； R4 is phenyl, naphthyl, (TO)Tetrahidronaftilo, indenilo, or where indanilo, phenyl, naphthyl, or indanilo indenilo tetrahidronaftilo,, are optionally substituted with one or more)； or (b) heterociclilo monocyclic, bicyclic or tricyclic between 5 and 16 members, where the heterociclilo is optionally substituted with One or more R5, R6； in each case, is independently NS, NO2, Halo, alkyl C1 - 6, org, SRG, RG, C (o)C (o) C (o) nrhri, org, nrhri, nrhc (RG), S (OR) nrhs 2RG 2RG, (OR), S (OR) 2nrhri, cycloalkyl, aryl, heteroaryl, or heterocicloalquilo, heterocicloalquenilo C1 - 6, where the rent is optionally substituted with one or more substituents selected among The Group of NS, Halo, Hydroxy, S (o) 2nh (alkyl, alkoxy C1 C1 - 6) - 6, heterocicloalquilo, cycloalkyl, aryl, heteroaryl, - NH2,- NH - C1 - 6 alkyl, and N - (alkyl C1 - 6) 2, cycloalkyl, aryl, heteroaryl or heterocicloalquilo, alone or as part of another portion, is optionally substituted with one or more R6, R7； in each case, is independently NS, NO2, Halo, cycloalkyl C3 - 8, orj, s.r.j.,
