BACHMANN MARTIN F.,MARTIN F. BACHMANN,TISSOT ALAIN,ALAIN TISSOT,ORTMANN RAINER,RAINER ORTMANN,LÜÖND RAINER,RAINER LÜÖND,STAUFENBIEL MATTHIAS,MATTHIAS STAUFENBIEL,FREY PETER,PETER FREY
申请号：
PL374935
公开号：
PL217409B1
申请日:
2003.07.18
申请国别(地区):
PL
年份:
2014
代理人:
摘要：
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an A²1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one A²1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimer's disease and as a pharmaccine to prevent or cure Alzheimer's disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
