Martin F. BACHMANN,Alain TISSOT,Rainer ORTMANN,Rainer LUEOEND,Matthias STAUFENBIEL,Peter FREY
申请号：
US14105701
公开号：
US20140294876A1
申请日:
2013.12.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular an Aβ1-6 peptide-VLP-composition. More specifically, the invention provides a composition comprising a virus-like particle and at least one Aβ1-6 peptide bound thereto. The invention also provides a process for producing the conjugates and the ordered and repetitive arrays, respectively. The compositions of the invention are useful in the production of vaccines for the treatment of Alzheimers disease and as a pharmaccine to prevent or cure Alzheimers disease and to efficiently induce immune responses, in particular antibody responses. Furthermore, the compositions of the invention are particularly useful to efficiently induce self-specific immune responses within the indicated context.
