Oral preparation (I) for controlled release of active ingredient in small intestine, comprises at least one active ingredient based on active ingredient carrier, where the active ingredient is provided with an internal layer for controlling the active ingredient release, and a covering layer that is resistant to gastric juice, where the inner layer is constructed with at least two diffusion layer, whose permeability for diffusing the active ingredient decreases from inside to outside, and the diffusion layer are formed from a matrix material insoluble in the small intestine juice. Oral preparation for controlled release of active ingredient in small intestine, comprises at least one active ingredient based on active ingredient carriers, where the active ingredient is provided with an internal layer for controlling the active ingredient release, and a covering layer that is resistant to gastric juice, where the inner layer is constructed with at least two diffusion layers, whose permeability for diffusing the active ingredient decreases from inside to outside, and the diffusion layer are formed from a matrix material insoluble in the small intestine juice, whose permeability for diffusing active ingredient is embedded with gastric juice soluble, swellable and/or water absorbing pore forming material. An INDEPENDENT CLAIM is included for the preparation of (I) comprising coating active ingredient carrier with solution or suspension containing binder, releasing agent and optionally buffer substance, providing at least two diffusion layer, whose permeability for diffusing active ingredient decreases from inside to outside, and applying a gastric juice resistance coating layer, optionally with a saliva-resistant external layer. - ACTIVITY : None given. - MECHANISM OF ACTION : None given.活性成分の放出を制御した内層と、その上に配された胃液耐性の被覆層とを備え、その内層が少なくとも2つの拡散層から形成され、拡散する活性成分に対するその拡散層の浸透性が内側から外側に向けて減少することを特徴とする活性成分担体と、少なくとも1つの活性成分とをベースとした小腸における活性成分の放出を制御した経口投与用の医薬品製剤、およびその製造方法が記載されている。【選択図】なし
