Oral preparation (I) for controlled release of active ingredient in small intestine, comprises at least one active ingredient based on active ingredient carrier, where the active ingredient is provided with an internal layer for controlling the active ingredient release, and a covering layer that is resistant to gastric juice, where the inner layer is constructed with at least two diffusion layer, whose permeability for diffusing the active ingredient decreases from inside to outside, and the diffusion layer are formed from a matrix material insoluble in the small intestine juice. Oral preparation for controlled release of active ingredient in small intestine, comprises at least one active ingredient based on active ingredient carriers, where the active ingredient is provided with an internal layer for controlling the active ingredient release, and a covering layer that is resistant to gastric juice, where the inner layer is constructed with at least two diffusion layers, whose permeability for diffusing the active ingredient decreases from inside to outside, and the diffusion layer are formed from a matrix material insoluble in the small intestine juice, whose permeability for diffusing active ingredient is embedded with gastric juice soluble, swellable and/or water absorbing pore forming material. An independent claim is included for the preparation of (I) comprising coating active ingredient carrier with solution or suspension containing binder, releasing agent and optionally buffer substance, providing at least two diffusion layer, whose permeability for diffusing active ingredient decreases from inside to outside, and applying a gastric juice resistance coating layer, optionally with a saliva-resistant external layer. ACTIVITY : None given. MECHANISM OF ACTION : None given.활성성분의 방출을 제어하기 위한 내층 및 내층 상에 형성된 위 저항성 코팅층(gastro-resistant coating layer)을 구비한 적어도 1개의 활성성분을 함유하는, 활성성분 담체에 기초하여, 소장 내에서 활성성분의 방출이 제어되는 경구투여용 약제학적 조제물에 관한 것으로서, 상기 내층은 확산성 활성성분의 투과도가 내측에서 외측
