RUSLI ISMAIL,MOHAMED ASHRAF ALI,TAN SOO CHOON,YEONG KENG YOON,ANG CHEE WEI,RAJU SURESH KUMAR,HASNAH OSMAN
申请号：
MYPI 2011000318
公开号：
MY160076A
申请日:
2011.01.21
申请国别(地区):
MY
年份:
2017
代理人:
摘要：
ACCORDINGLY, THE INVENTION DISCLOSES COMPOUNDS WITH ENHANCED BIOAVAILABILITY FOR THE PREVENTION AND TREATMENT OF ANTI-HUMAN IMMUNODEFICIENCY VIRUS (HIV), ANTI-TUBERCULOSIS (TB), ANTI-ALZHEIMER OR ANTI-CANCER. THE INVENTION ALSO DISCLOSES THE METHOD IN SYNTHESIZING THESE COMPOUNDS WHEREIN THE STEPS INCLUDES MIXING CURCUMIN, ISATIN DERIVATIVES OR NINHYDRIN AND PIPECOLINIC ACID IN 20 ML METHANOL. THE MIXTURE WAS THEN REFLUXED WITH A SOLVENT ON A WATER BATH AND EXCESS SOLVENT WAS REMOVED UNDER VACUUM. THE RESIDUE SUBJECTED TO FLASH COLUMN CHROMATOGRAPHY USING PETROLEUM ETHER: ETHYL ACETATE MIXTURE (4:1) AS ELUENT TO AFFORD THE PRODUCT. THE RATIO FOR CURCUMIN: ISATIN DERIVATIVE/NINHYDRIN: PIPECOLINIC ACID IS 1:1:2 AND 1:2:4.
