A food supplement omega 3 based on marine oils (extracted from fish, fish byproducts, mollusks, krill, algae, microalgae) to fight against hypercholesterolemia and lipoprotein disruption leading to atherosclerosis and so to cardiovascular diseases. Optimization of Lipid Prevention Score (LPS) of at least one food supplement omega 3 by adding either high or low LPS oil (vegetable and/or marine) according to the LPS of the omega 3 based marine oils. This action permits to make a well balanced fatty acid product that will have a better effect against the rising of bad cholesterol levels in the blood. This product can be prescribed as part of a preventive diet and/or curative treatment for cardiovascular diseases since such illnesses lead to the highest human mortality in the industrialized countries (about 180,000 deaths annually in France, which corresponds to 32% of total deaths).