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Procedure for the preparation of 4-phenyl butyrate and uses thereof
专利权人:
Horizon Therapeutics; LLC
发明人:
Huai-Chueh Chang,Steven S. Pfeiffer,Vasilios H. Iskos,Maki Uragami,Steven Weissman,Andrew Thompson
申请号:
US15164126
公开号:
US09914692B2
申请日:
2016.05.25
申请国别(地区):
US
年份:
2018
代理人:
摘要:
Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
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