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P-TOLUÈNESULFONATE POUR INHIBITEUR DE KINASE MEK, FORME CRISTALLINE DE CELUI-CI ET PROCÉDÉ DE PRÉPARATION DE CELUI-CI
专利权人:
Jiangsu Hengrui Medicine Co.; Ltd.
发明人:
申请号:
EP16771228.0
公开号:
EP3275866B1
申请日:
2016.03.08
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
Disclosed are a p-toluenesulfonate for an MEK kinase inhibitor, and a crystal form thereof and a preparation method therefor. Specifically, disclosed are a 2-((2-fluorine-4-iodophenyl)amino)-1-methyl-4-((6-methylpyridine-3-group)oxygroup)-6-carbonyl-1,6-dihydropyridine-3-formamide p-toluenesulfonate (a compound represented by formula (I)), and an I-form crystal and a preparation method therefor. The obtained I-form crystal of the compound represented by formula (I) has good crystal form stability and chemical stability, and a used crystallization solvent has low toxicity and low residue and can be better used in clinical treatment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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