Novel tools and techniques are provided for implementing item or luggage loss prevention, which, in some cases, is based on weight measurement. In some embodiments, a device with a processor can be placed under a bags handle, within an interior compartment of the bag, below or in the feet or wheels of the bag, and/or the like. The device can allow a user to lock in a weight of the bag. If any item is subsequently removed from (and not returned to) the bag, the device will notify the user, using one or more of audio notification, visual notification, and/or mobile device notification (e.g., via e-mail, text message, SMS, MMS, chat message, and/or the like) that the weight of the bag has changed. In some cases, location detection devices may be implemented to allow the user to backtrack where the missing item might have been left behind.