AMINOCHROMANE, AMINOTHIOCHROMANE AND AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY农业专利-农业学术服务平台

发明人:: AMBERG, WILHELM,艾姆柏格威惠牡,艾姆柏格威惠牡,LANGE, UDO,兰吉伍杜,蘭吉伍杜,POHLKI, FRAUKE,普基法罗克,普基法羅克

摘要：: The present invention relates to aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives of the formula (I) or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline deriva-tives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.本發明係關於式(I)之胺基唍、胺基硫唍及胺基-1,2,3,4-四氫喹啉衍生物或其生理學上可耐受之鹽。本發明係關於包含該等胺基唍、胺基硫唍及胺基-1,2,3,4-四氫喹啉衍生物之醫藥組合物,及該等胺基唍、胺基硫唍及胺基-1,2,3,4-四氫喹啉衍生物用於治療性目的之用途。該等胺基唍、胺基硫唍及胺基-1,2,3,4-四氫喹啉衍生物為GlyT1抑制劑。