Disclosed are methods, compositions and kits pertaining to controlled delivery of compounds. In certain aspects and embodiments the present technology relates to compositions and methods for controlled delivery of a compound such as a bioactive compound which involve exposing a matrix comprising the bioactive compound, a crosslinkable monomer and a polymerization initiator to an external stimulus； wherein the external stimulus causes crosslinking of the matrix. In some embodiments, the crosslinking causes a decrease in the release of the compound from the matrix.
