Yelm, Kenneth Edward,Bunke, Gregory Mark,Haught, John Christian
申请号：
AU2009281914
公开号：
AU2009281914B2
申请日:
2009.08.13
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as
