The present disclosure provides composition, manufacturing method and the application methods of the antibody and segment that combine staphylococcus aureus alpha toxin. More precisely, the present disclosure provides VH CDR and VL the CDR region sequences of antibody or antigen-binding fragment. Further disclose the method for preventing, treating or managing illness relevant to infection of staphylococcus aureus.本披露提供了結合金黃色葡萄球菌α毒素的抗體和片段的組合物、製造方法以及使用方法。更確切地說,本披露提供了抗體或抗原結合片段的VH CDR和VL CDR區序列。還披露了預防、治療或管理與金黃色葡萄球菌感染相關的病症的方法。